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Livres
Articles (122)
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Crystal structures of a GABAA-receptor chimera reveal new endogenous neurosteroid-binding sites

Laverty, Duncan, Thomas, Philip, Field, Martin, Andersen, Ole J, Gold, Matthew G, Biggin, Philip C, Gielen, Marc, Smart, Trevor G

Journal:

Nature Structural and Molecular Biology

Année:

2017

Langue:

english

Fichier:

PDF, 6.34 MB

english, 2017

Protein Structure in a Nutshell

Philip C. Biggin

Journal:

BioEssays

Année:

2001

Langue:

english

Fichier:

PDF, 29 KB

english, 2001

Comparative molecular dynamics—Similar folds and similar motions?

Andrew Pang, Yalini Arinaminpathy, Mark S. P. Sansom, Philip C. Biggin

Journal:

Proteins: Structure, Function, and Bioinformatics

Année:

2005

Langue:

english

Fichier:

PDF, 1.25 MB

english, 2005

Rigid body essential X-ray crystallography: Distinguishing the bend and twist of glutamate receptor ligand binding domains

Esben J. Bjerrum, Philip C. Biggin

Journal:

Proteins: Structure, Function, and Bioinformatics

Année:

2008

Langue:

english

Fichier:

PDF, 796 KB

english, 2008

Deltamethrin flea-control preserves genetic variability of black-tailed prairie dogs during a plague outbreak

Philip H. Jones, Dean E. Biggins, David A. Eads, Samantha L. Eads, Hugh B. Britten

Journal:

Conservation Genetics

Année:

2012

Langue:

english

Fichier:

PDF, 419 KB

english, 2012

Biophysics: Water at the nanoscale

Sansom, Mark S. P., Biggin, Philip C.

Journal:

Nature

Année:

2001

Langue:

english

Fichier:

PDF, 171 KB

english, 2001

10.1038/88618

Barton, William A., Lesniak, Jacob, Biggins, John B., Jeffrey, Philip D., Jiang, Jiqing, Rajashankar, K. R., Thorson, Jon S., Nikolov, Dimitar B.

Journal:

Natural Structural Biology

Année:

2001

Langue:

english

Fichier:

PDF, 4.36 MB

english, 2001

Channel gating: Twist to open

Philip C Biggin, Mark S.P Sansom

Journal:

Current Biology

Année:

2001

Langue:

english

Fichier:

PDF, 178 KB

english, 2001

Glutamate Receptors: Desensitizing Dimers

Philip C Biggin

Journal:

Current Biology

Année:

2002

Langue:

english

Fichier:

PDF, 344 KB

english, 2002

Mechanosensitive Channels: Stress Relief

Philip C Biggin, Mark S.P Sansom

Journal:

Current Biology

Année:

2003

Langue:

english

Fichier:

PDF, 819 KB

english, 2003

Dynamics based alignment of proteins: an alternative approach to quantify dynamic similarity

Márton Münz, Rune Lyngsø, Jotun Hein, Philip C Biggin

Journal:

BMC Bioinformatics

Année:

2010

Langue:

english

Fichier:

PDF, 6.87 MB

english, 2010

A7DB: a relational database for mutational, physiological and pharmacological data related to the α7 nicotinic acetylcholine receptor

Steven D Buckingham, Luanda Pym, Andrew K Jones, Laurence Brown, Mark SP Sansom, David B Sattelle, Philip C Biggin

Journal:

BMC Neuroscience

Année:

2005

Langue:

english

Fichier:

PDF, 237 KB

english, 2005

Molecular Basis of Kainate Receptor Modulation by Sodium

Andrew J.R. Plested, Ranjit Vijayan, Philip C. Biggin, Mark L. Mayer

Journal:

Neuron

Année:

2008

Langue:

english

Fichier:

PDF, 2.43 MB

english, 2008

Potassium channels: structures, models, simulations

Mark S.P. Sansom, Indira H. Shrivastava, Joanne N. Bright, John Tate, Charlotte E. Capener, Philip C. Biggin

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Année:

2002

Langue:

english

Fichier:

PDF, 756 KB

english, 2002

Interdomain dynamics and ligand binding: molecular dynamics simulations of glutamine binding protein

Andrew Pang, Yalini Arinaminpathy, Mark S.P. Sansom, Philip C. Biggin

Journal:

FEBS Letters

Année:

2003

Langue:

english

Fichier:

PDF, 517 KB

english, 2003

Ion channel gating: insights via molecular simulations

Oliver Beckstein, Philip C Biggin, Peter Bond, Joanne N Bright, Carmen Domene, Alessandro Grottesi, John Holyoake, Mark S.P Sansom

Journal:

FEBS Letters

Année:

2003

Langue:

english

Fichier:

PDF, 435 KB

english, 2003

A prokaryotic glutamate receptor: homology modelling and molecular dynamics simulations of GluR0

Yalini Arinaminpathy, Philip C. Biggin, Indira H. Shrivastava, Mark S.P. Sansom

Journal:

FEBS Letters

Année:

2003

Langue:

english

Fichier:

PDF, 434 KB

english, 2003

Open-State Models of a Potassium Channel

Biggin, Philip C., Sansom, Mark S.P.

Journal:

Biophysical Journal

Année:

2002

Langue:

english

Fichier:

PDF, 457 KB

english, 2002

K+ versus Na+ Ions in a K Channel Selectivity Filter: A Simulation Study

Shrivastava, Indira H., Peter Tieleman, D., Biggin, Philip C., Sansom, Mark S.P.

Journal:

Biophysical Journal

Année:

2002

Langue:

english

Fichier:

PDF, 506 KB

english, 2002

Molecular Dynamics Simulations of the Ligand-Binding Domain of the Ionotropic Glutamate Receptor GluR2

Arinaminpathy, Yalini, Sansom, Mark S.P., Biggin, Philip C.

Journal:

Biophysical Journal

Année:

2002

Langue:

english

Fichier:

PDF, 264 KB

english, 2002

Determination of Pore-Lining Residues in the Hepatitis C Virus p7 Protein

Chew, Chee Foong, Vijayan, Ranjit, Chang, Jason, Zitzmann, Nicole, Biggin, Philip C.

Journal:

Biophysical Journal

Année:

2009

Langue:

english

Fichier:

PDF, 268 KB

english, 2009

Selectivity and Cooperativity of Modulatory Ions in a Neurotransmitter Receptor

Vijayan, Ranjit, Plested, Andrew J.R., Mayer, Mark L., Biggin, Philip C.

Journal:

Biophysical Journal

Année:

2009

Langue:

english

Fichier:

PDF, 991 KB

english, 2009

Ionontropic Glutamate Receptors: Insight into the Mechanism of Desensitization and Deactivation using Molecular Dynamics Simulations

Amara, Najette, Vijayan, Ranjit, Biggin, Philip C., Iorga, Bogdan I.

Journal:

Biophysical Journal

Année:

2012

Langue:

english

Fichier:

PDF, 38 KB

english, 2012

An interview with Philip Biggin, Section Editor for Computational,in silicoand modelling studies

Biggin, Philip C

Journal:

BMC Pharmacology and Toxicology

Année:

2012

Langue:

english

Fichier:

PDF, 109 KB

english, 2012

A Steroid in a Lipid Bilayer: Localization, Orientation, and Energetics

Vijayan, Ranjit, Biggin, Philip C.

Journal:

Biophysical Journal

Année:

2008

Langue:

english

Fichier:

PDF, 280 KB

english, 2008

Distribution and Dynamics of Adamantanes in a Lipid Bilayer

Chew, Chee Foong, Guy, Andrew, Biggin, Philip C.

Journal:

Biophysical Journal

Année:

2008

Langue:

english

Fichier:

PDF, 645 KB

english, 2008

Substrate versus inhibitor dynamics of P-glycoprotein

Ma, Jerome, Biggin, Philip C.

Journal:

Proteins: Structure, Function, and Bioinformatics

Année:

2013

Langue:

english

Fichier:

PDF, 2.89 MB

english, 2013

Study of Human Orexin-1 and -2 G-Protein-Coupled Receptors with Novel and Published Antagonists by Modeling, Molecular Dynamics Simulations, and Site-Directed Mutagenesis

Heifetz, Alexander, Morris, G. Benjamin, Biggin, Philip C., Barker, Oliver, Fryatt, Tara, Bentley, Jonathan, Hallett, David, Manikowski, Dominique, Pal, Sandeep, Reifegerste, Rita, Slack, Mark, Law, R

Journal:

Biochemistry

Année:

2012

Langue:

english

Fichier:

PDF, 1.05 MB

english, 2012

The influence of different lipid environments on the structure and function of the hepatitis C virus p7 ion channel protein

Whitfield, Thomas, Miles, Andrew J., Scheinost, Johanna C., Offer, John, Wentworth Jr, Paul, Dwek, Raymond A., Wallace, B. A., Biggin, Philip C., Zitzmann, Nicole

Journal:

Molecular Membrame Biology

Année:

2011

Langue:

english

Fichier:

PDF, 611 KB

english, 2011

In Silico Mutation of Cysteine Residues in the Ligand-Binding Domain of an N -Methyl- d -aspartate Receptor †

Kaye, Samantha L., Sansom, Mark S. P., Biggin, Philip C.

Journal:

Biochemistry

Année:

2007

Langue:

english

Fichier:

PDF, 372 KB

english, 2007

JGromacs: A Java Package for Analyzing Protein Simulations

Münz, Márton, Biggin, Philip C.

Journal:

Journal of Chemical Information and Modeling

Année:

2012

Langue:

english

Fichier:

PDF, 1.63 MB

english, 2012

The dynamics of camphor in the cytochrome P450 CYP101D2

Vohra, Shabana, Musgaard, Maria, Bell, Stephen G., Wong, Luet-Lok, Zhou, Weihong, Biggin, Philip C.

Journal:

Protein Science

Année:

2013

Langue:

english

Fichier:

PDF, 3.92 MB

english, 2013

Defining the structural relationship between kainate-receptor deactivation and desensitization

Dawe, G Brent, Musgaard, Maria, Andrews, Elizabeth D, Daniels, Bryan A, Aurousseau, Mark R P, Biggin, Philip C, Bowie, Derek

Journal:

Nature Structural and Molecular Biology

Année:

2013

Langue:

english

Fichier:

PDF, 1.89 MB

english, 2013

One Size Does Not Fit All: The Limits of Structure-Based Models in Drug Discovery

Ross, Gregory A., Morris, Garrett M., Biggin, Philip C.

Journal:

Journal of Chemical Theory and Computation

Année:

2013

Langue:

english

Fichier:

PDF, 1.02 MB

english, 2013

Toward an Understanding of Agonist Binding to Human Orexin-1 and Orexin-2 Receptors with G-Protein-Coupled Receptor Modeling and Site-Directed Mutagenesis

Heifetz, Alexander, Barker, Oliver, Morris, G. Benjamin, Law, Richard J., Slack, Mark, Biggin, Philip C.

Journal:

Biochemistry

Année:

2013

Langue:

english

Fichier:

PDF, 7.11 MB

english, 2013

Towards understanding promiscuity in multidrug efflux pumps

Wong, Kelvin, Ma, Jerome, Rothnie, Alice, Biggin, Philip C., Kerr, Ian D.

Journal:

Trends in Biochemical Sciences

Année:

2014

Langue:

english

Fichier:

PDF, 2.58 MB

english, 2014

Deciphering the Relationship Between Hepatitis C Virus (HCV) P7 and Its Foes

Chew, Chee Foong, Zitzmann, Nicole, Biggin, Philip C.

Journal:

Biophysical Journal

Année:

2010

Langue:

english

Fichier:

PDF, 55 KB

english, 2010

Protein Similarity Derived Solely from Molecular Dynamics

Biggin, Philip C., Lyngsø, Rune, Hein, Jotun, Münz, Márton

Journal:

Biophysical Journal

Année:

2010

Langue:

english

Fichier:

PDF, 37 KB

english, 2010

Re-Evaluating a Proposed Mechanism for Ion Modulation in Kainate Receptors

Dawe, George B., Daniels, Bryan A., Andrews, Elizabeth D., Aurousseau, Mark R., Musgaard, Maria, Biggin, Philip C., Bowie, Derek

Journal:

Biophysical Journal

Année:

2013

Langue:

english

Fichier:

PDF, 37 KB

english, 2013

Studies of the Conformational Dynamics of Ligand and Nucleotide Bound P-Glycoprotein

Ma, Jerome, Biggin, Philip C.

Journal:

Biophysical Journal

Année:

2013

Langue:

english

Fichier:

PDF, 42 KB

english, 2013

Atomistic Simulations Explain Mutational Effects on Ion Modulation and Kainate Receptor Activity

Musgaard, Maria, Daniels, Bryan, Andrews, Elizabeth, Dawe, G. Brent, Aurousseau, Mark, Bowie, Derek, Biggin, Philip C.

Journal:

Biophysical Journal

Année:

2013

Langue:

english

Fichier:

PDF, 60 KB

english, 2013

Functional Consequences of Cysteine Mutations at the Kainate Receptor Dimer Interface

Daniels, Bryan A., Aurousseau, Mark R.P., Musgaard, Maria, Dawe, George B., Biggin, Philip C., Bowie, Derek

Journal:

Biophysical Journal

Année:

2014

Langue:

english

Fichier:

PDF, 44 KB

english, 2014

Regulatory Ions Bound at the iGluR Ligand Binding Domain Dimer Interface - A Shared Property of GluK2 and AvGluR1?

Musgaard, Maria, Barber, Jack, bin Imtiaz, M. Khadeesh, Biggin, Philip C.

Journal:

Biophysical Journal

Année:

2014

Langue:

english

Fichier:

PDF, 41 KB

english, 2014

Protein dynamics – a moving target

Biggin, Philip C.

Journal:

Physics of Life Reviews

Année:

2013

Langue:

english

Fichier:

PDF, 64 KB

english, 2013

A Comparative Molecular Dynamics Simulation Study of the Amino Terminal Domain of Ionotropic Glutamate Receptors

Vijayan, Ranjit, Biggin, Philip C.

Journal:

Biophysical Journal

Année:

2010

Langue:

english

Fichier:

PDF, 32 KB

english, 2010

Combining Modelling and Site-Directed Mutagenesis to Explore Agonist Binding to Human Orexin Receptors

Heifetz, Alexander, Barker, Oliver, Morris, G. Benjamin, Law, Richard J., Slack, Mark, Biggin, Philip C.

Journal:

Biophysical Journal

Année:

2014

Langue:

english

Fichier:

PDF, 48 KB

english, 2014

Interaction of the Glycine Receptor Alpha 1 Binding Site with Partial Agonists

Greiner, Timo, Hurdiss, Elliot, Yu, Rilei, Lape, Remigijus, Biggin, Philip C., Sivilotti, Lucia G.

Journal:

Biophysical Journal

Année:

2014

Langue:

english

Fichier:

PDF, 47 KB

english, 2014

An Ionic Switch in the Ligand-Binding Domain of Non-NMDA Receptors

Vijayan, Ranjit, Biggin, Philip C.

Journal:

Biophysical Journal

Année:

2012

Langue:

english

Fichier:

PDF, 38 KB

english, 2012

Extending the Structure of an ABC Transporter to Atomic Resolution: Modeling and Simulation Studies of MsbA †

Campbell, Jeff D., Biggin, Philip C., Baaden, Marc, Sansom, Mark S. P.

Journal:

Biochemistry

Année:

2003

Langue:

english

Fichier:

PDF, 431 KB

english, 2003

Characterization of Protein Conformational States by Normal-Mode Frequencies

Hall, Benjamin A., Kaye, Samantha L., Pang, Andy, Perera, Rafael, Biggin, Philip C.

Journal:

Journal of the American Chemical Society

Année:

2007

Langue:

english

Fichier:

PDF, 615 KB

english, 2007